Any human studies of Calcium AKG and increased lifespan?

I recently have been interested in longevity which I believe is a field that will be massively growing in the coming years, and one supplement that has been getting a lot of attention lately is Calcium AKG, because is easier to get that some other “cutting edge” supplements, and does have some pretty good studies to support it as being a longevity drug. Most of the studies are in mice, and it’s pretty incredible how it has extended lifespan by more than 10%. The problem with studying humans is we don’t have the ability to quickly see someone’s increased lifespan.

My friend was asking if there are any human studies, and there is one (link to more info about the study) that looks promising but was only in a small sample group. There is a product called Rejuvant (which is just Calcium AKG). Participants in the study took Rejuvant plus Vitamin A for men and Vitamin D for women. Then they used TruAge DNA methylation to evaluate epigenetic markers associated with aging. The findings:

• Participants experienced an average reduction of approximately 8 years in biological age after the supplementation period.
• The decrease in biological age was statistically significant (p-value = 6.538 × 10⁻¹²).
• The effect was consistent across participants, with both men and women showing reductions in biological age.

But the study also had some limitations:

• The study lacked a placebo-controlled group, which limits the ability to attribute the effects solely to the supplement.
• Participants were self-selected and purchased the supplement and testing kits independently, introducing potential selection bias. There were just 42 participants (28 men and 14 women)
• The study did not isolate the effects of Ca-AKG from the added vitamins (A or D), making it unclear which component(s) contributed most to the observed effects.

But there is another clinical trial going on now in Singapore (with three races of people, I think Malaysian, Chinese and Indonesian) with more robust data including a control group and a larger sample size, and it should be published this year.

How Calcium AKG Works

Ca-AKG is a key intermediate in the Krebs cycle and plays a role in energy metabolism. It is also involved in epigenetic regulation through its role as a cofactor for dioxygenase enzymes, which can influence DNA and histone methylation. These properties suggest potential mechanisms by which Ca-AKG could impact biological aging, although more research is needed to fully understand these effects in humans.